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Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes

Abstract:

Background. There is a heritable component to suicidal behaviour, encouraging the search for the associated risk alleles. Given the putative role of the 5-HT (5-hydroxytryptamine; serotonin) system in suicidal behaviour, serotonergic genes are leading candidates. In particular, several studies have reported an association with variants in the tryptophan hydroxylase (TPH) gene. Method. We studied six serotonergic gene polymorphisms in a well-characterized sample of 129 deliberate self-harm sub...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1017/S0033291703007463

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Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Centre for Suicide Research
Department:
Medical Sciences Division - Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Psychiatry
Role:
Author
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Funding agency for:
E. C. Pooley
American Foundation for Suicide Prevention More from this funder
Anglia and Oxford Research and Development Committee More from this funder
Publisher:
Cambridge University Press Publisher's website
Journal:
Psychological Medicine Journal website
Volume:
33
Issue:
5
Pages:
775-783
Publication date:
2003-07-05
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
URN:
uuid:3ae3c858-17c7-433d-a7a3-012e6037a9e7
Local pid:
ora:1470

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