Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors.

Journal article

The observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genotypic changes during culture of a multinucleoside (zidovudine, didanosine, zalcitibine, and stavudine)-resistant HIV-1 strain with and without additional RT inhibitors (nevirapine and lamivudine). T...

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Authors: Shafer, R; Winters, M; Iversen, A; Merigan, T

• Journal: Antimicrobial agents and chemotherapy
• Volume: 40
• Issue: 12
• Pages: 2887-2890
• Publication date: 1996-12-01
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Drug Resistance, Multiple; Didanosine; Drug Interactions; Reverse Transcriptase Inhibitors; Pyridines; Zidovudine; Virus Replication; Cells, Cultured; HIV-1; Drug Resistance, Microbial; Antiviral Agents; Mutation; Genotype; Lamivudine; Cell Line; Humans; Nevirapine