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Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses.

Abstract:

The thymus has been shown to play an important role in the generation of T cell tolerance to self antigens. Developing T cells are readily tolerized to antigens which are expressed in the thymus, and it is generally thought that such thymic tolerance occurs by a mechanism of clonal deletion. We sought to examine whether T cells which initially encountered a "self antigen" post-thymically would be rendered tolerant of that antigen, and if so whether the mechanism of tolerance induction would d...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830190118

Authors


Zamoyska, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Matzinger, P More by this author
Journal:
European journal of immunology
Volume:
19
Issue:
1
Pages:
111-117
Publication date:
1989-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3ac6a835-03e7-4b0a-a361-47df5d6a9169
Source identifiers:
29167
Local pid:
pubs:29167

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