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The apparent increase in the {beta}-parameter of the linear quadratic model with increased linear energy transfer during fast neutron irradiation.

Abstract:

The issue of whether the beta-parameter of the linear quadratic model changes with linear energy transfer (LET) remains controversial. Retrospective analysis of UK fast neutron experimental data using human cell lines at Clatterbridge shows that the beta-parameter of the linear quadratic model probably does increase with LET during neutron irradiation. For cells without a deficiency in DNA damage repair and for experiments in which beta-parameter estimates were considered to be unreliably low...

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Publication status:
Published

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Publisher copy:
10.1259/bjr/68792966

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
The British journal of radiology
Volume:
83
Issue:
989
Pages:
433-436
Publication date:
2010-05-05
DOI:
EISSN:
1748-880X
ISSN:
0007-1285
URN:
uuid:3ac47bee-631e-4f6a-9cfa-5c77cab1e5d5
Source identifiers:
131037
Local pid:
pubs:131037

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