- Abstract:
-
BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Determination of the three-dimensional structure of the enzyme should form the basis for design of more potent and selective therapeutic agents for treatment of the disease. RESULTS: The structure of P....
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0969-2126(94)00093-x
-
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- Journal:
- Structure (London, England : 1993)
- Volume:
- 2
- Issue:
- 10
- Pages:
- 915-924
- Publication date:
- 1994-10-05
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- URN:
-
uuid:3ac2a672-5b30-42f6-8a0e-f523ae59d1db
- Source identifiers:
-
72688
- Local pid:
- pubs:72688
- Language:
- English
- Keywords:
- Copyright date:
- 1994
Journal article
The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
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