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The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

Abstract:

BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Determination of the three-dimensional structure of the enzyme should form the basis for design of more potent and selective therapeutic agents for treatment of the disease. RESULTS: The structure of P....

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Publication status:
Published

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Journal:
Structure (London, England : 1993)
Volume:
2
Issue:
10
Pages:
915-924
Publication date:
1994-10-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Source identifiers:
72688

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