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The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.

Abstract:

BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Determination of the three-dimensional structure of the enzyme should form the basis for design of more potent and selective therapeutic agents for treatment of the disease. RESULTS: The structure of P....

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Publication status:
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Authors


Champness, JN More by this author
Ballantine, SP More by this author
Bryant, PK More by this author
Delves, CJ More by this author
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Journal:
Structure (London, England : 1993)
Volume:
2
Issue:
10
Pages:
915-924
Publication date:
1994-10-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:3ac2a672-5b30-42f6-8a0e-f523ae59d1db
Source identifiers:
72688
Local pid:
pubs:72688

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