Advances in the biology of bone metastasis: how the skeleton affects tumor behavior.

Journal article

It is increasingly evident that the microenvironment of bone can influence the cancer phenotype in many ways that favor growth in bone. The ability of cancer cells to adhere to bone matrix and to promote osteoclast formation are key requirements for the establishment and growth of bone metastases. Several cytokine products of breast cancers (e.g. PTHrP, IL-11, IL-8) have been shown to act upon host cells of the bone microenvironment to promote osteoclast formation, allowing for excessive bone...

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Authors: Sterling, J; Edwards, J; Martin, T; Mundy, G

• Publication status: Published
• Journal: Bone
• Volume: 48
• Issue: 1
• Pages: 6-15
• Publication date: 2011-01-01
• DOI: 10.1016/j.bone.2010.07.015
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Osteoclasts; Humans; Osteoblasts; Bone Resorption; Transforming Growth Factor beta; Interleukin-8; Bone Neoplasms; Bone and Bones; Parathyroid Hormone-Related Protein; Interleukin-11; Cytokines; Female; Breast Neoplasms; Osteogenesis; Neoplasms