- Abstract:
-
The activities of 28 6-substituted 2,4-diaminoquinazolines, 2,4-diamino-5,6,7,8-tetrahydroquinazolines, and 2,4-diaminopteridines against Plasmodium falciparum were tested. The 50% inhibitory concentrations (IC 50s) of six compounds were <50 nM, and the most potent compound was 2,4-diamino-5-chloro-6-[N-(2,5-dimethoxybenzyl)amino]quinazoline (compound 1), with an IC50 of 9 nM. The activity of compound 1 was potentiated by the dihydropteroate synthase inhibitor dapsone, an indication that t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/ACC.48.10.3711-3714.2004
-
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- Journal:
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Volume:
- 48
- Issue:
- 10
- Pages:
- 3711-3714
- Publication date:
- 2004-10-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:3ab899bb-fd39-4fb8-8f12-943c369db7d7
- Source identifiers:
-
39180
- Local pid:
- pubs:39180
- Language:
- English
- Copyright date:
- 2004
Journal article
In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum
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