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Journal article

Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina.

Abstract:

Retinal stem cells have been isolated from the ciliary epithelium (CE) of the mammalian retina. However, the central neural retina (CNR) lacks the capability to regenerate, a phenomenon retained by lower vertebrates. Mutations in the Chx10 homeobox gene cause reduced proliferation of retinal progenitor cells during development, leading to microphthalmia. Recently, we showed that in Chx10(orJ/orJ) mice, dividing cells persist in the adult CNR, suggesting the existence of a dormant progenitor p...

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Publication status:
Published

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Publisher copy:
10.1016/j.mcn.2008.03.008

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Role:
Author
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Journal:
Molecular and cellular neurosciences
Volume:
38
Issue:
3
Pages:
359-373
Publication date:
2008-07-05
DOI:
EISSN:
1095-9327
ISSN:
1044-7431
URN:
uuid:3ab5d81b-c91c-4062-8476-1840c4f5a910
Source identifiers:
107254
Local pid:
pubs:107254

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