Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial.

Journal article

BACKGROUND: Osteoarthritis (OA) is the most common type of arthritis, causing significant joint pain and disability. It is already a major cause of healthcare expenditure and its incidence will further increase with the ageing population. Current treatments for OA have major limitations and new analgesic treatments are needed. Synovitis is prevalent in OA and is associated with pain. Hydroxychloroquine is used in routine practice for treating synovitis in inflammatory arthritides, such as rh...

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Authors: Kingsbury, SR; Tharmanathan, P; Adamson, J; Arden, N; Birrell, F

• Publication status: Published
• Journal: Trials
• Volume: 14
• Issue: 1
• Pages: 64
• Publication date: 2013-01-01
• DOI: 10.1186/1745-6215-14-64
• EISSN: 1745-6215
• ISSN: 1745-6215
• Language: English
• Keywords: Drug Costs; Linear Models; Patient Selection; Treatment Outcome; Synovitis; Multivariate Analysis; Arthralgia; Quality of Life; Pain Measurement; Primary Health Care; Hydroxychloroquine; Great Britain; Logistic Models; Time Factors; Intention to Treat Analysis; Osteoarthritis; Activities of Daily Living; Research Design; Hand Joints; Analgesics; Costs and Cost Analysis; Clinical Protocols; Recovery of Function; Humans; Double-Blind Method