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Evaluation of viremia frequencies of a novel human pegivirus by using bioinformatic screening and PCR

Abstract:

Next-generation sequencing has critical applications in virus discovery, diagnostics, and environmental surveillance. We used metagenomic sequence libraries for retrospective screening of plasma samples for the recently discovered human hepegivirus 1 (HHpgV-1). From a cohort of 150 hepatitis C virus (HCV)-positive case-patients, we identified 2 persons with HHpgV-1 viremia and a high frequency of human pegivirus (HPgV) viremia (14%). Detection of HHpgV-1 and HPgV was concordant with parallel ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3201/eid2204.151812

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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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More from this funder
Funding agency for:
Barnes, E
Grant:
Senior Clinical Fellow
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
Centers for Disease Control and Prevention Publisher's website
Journal:
Emerging Infectious Diseases Journal website
Volume:
22
Issue:
4
Pages:
671-678
Publication date:
2016-04-01
DOI:
EISSN:
1080-6059
ISSN:
1080-6040
Source identifiers:
616966
Language:
English
Keywords:
Pubs id:
pubs:616966
UUID:
uuid:3aae68a6-4644-4de9-99ea-d498fa81bfcd
Local pid:
pubs:616966
Deposit date:
2016-04-13

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