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An engineered dimeric protein pore that spans adjacent lipid bilayers.

Abstract:

The bottom-up construction of artificial tissues is an underexplored area of synthetic biology. An important challenge is communication between constituent compartments of the engineered tissue, and between the engineered tissue and additional compartments, including extracellular fluids, further engineered tissue and living cells. Here we present a dimeric transmembrane pore that can span two adjacent lipid bilayers, and thereby allow aqueous compartments to communicate. Two heptameric staph...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms2726

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author
Journal:
Nature communications
Volume:
4
Pages:
1725
Publication date:
2013-01-01
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Source identifiers:
395921
Language:
English
Keywords:
Pubs id:
pubs:395921
UUID:
uuid:3aa7aa43-78dd-49cd-8e01-ab97b73ae3fe
Local pid:
pubs:395921
Deposit date:
2013-11-16

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