Journal article
Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics.
- Abstract:
-
Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for systemic administration. We have developed a positive-readout pharmacodynamic transgenic reporter mouse model allowing noninvasive real-time assessment of siRNA activity. The model combines a luciferase reporter gene under the control of regulato...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/mtna.2013.63
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Authors
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Molecular therapy. Nucleic acids
- Volume:
- 2
- Issue:
- NOV
- Pages:
- e133
- Publication date:
- 2013-01-01
- DOI:
- EISSN:
-
2162-2531
- ISSN:
-
2162-2531
- Source identifiers:
-
440276
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:440276
- UUID:
-
uuid:3aa50685-14c0-4270-86cf-577941daf749
- Local pid:
- pubs:440276
- Deposit date:
- 2013-12-12
Terms of use
- Copyright date:
- 2013
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