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Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.

Abstract:

Despite substantial advances in our knowledge of immune responses against HIV-1 and of its evolution within the host, it remains unclear why control of the virus eventually breaks down. Here, we present a new theoretical framework for the infection dynamics of HIV-1 that combines antibody and CD8(+) T-cell responses, notably taking into account their different lifespans. Several apparent paradoxes in HIV pathogenesis and genetics of host susceptibility can be reconciled within this framework ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rstb.2014.0290

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Funding agency for:
Wikramaratna, P
Grant:
278433-PREDEMICS
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Funding agency for:
Klenerman, P
Grant:
WT091663MA
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Funding agency for:
Klenerman, P
Grant:
WT091663MA
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Funding agency for:
Pybus, O
Grant:
614725-PATHPHYLODYN
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Funding agency for:
Gupta, S
Grant:
268904-DIVERSITY
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Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions B: Biological Sciences Journal website
Volume:
370
Issue:
1675
Article number:
20140290
Publication date:
2015-08-01
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
Source identifiers:
531684
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:531684
UUID:
uuid:3aa434dd-9d16-4b33-91cd-f07f23b5afc9
Local pid:
pubs:531684
Deposit date:
2015-08-07

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