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RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.

Abstract:

H2B ubiquitylation has been implicated in active transcription but is not well understood in mammalian cells. Beyond earlier identification of hBRE1 as the E3 ligase for H2B ubiquitylation in human cells, we now show (1) that hRAD6 serves as the cognate E2-conjugating enzyme; (2) that hRAD6, through direct interaction with hPAF-bound hBRE1, is recruited to transcribed genes and ubiquitylates chromatinized H2B at lysine 120; (3) that hPAF-mediated transcription is required for efficient H2B ub...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2009.02.027

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Journal:
Cell
Volume:
137
Issue:
3
Pages:
459-471
Publication date:
2009-05-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:3a9c706d-3dba-4f59-b92b-943dc31bcccc
Source identifiers:
331899
Local pid:
pubs:331899

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