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Nanoparticle augmented radiation treatment decreases cancer cell proliferation.

Abstract:

UNLABELLED: We report significant and controlled cell death using novel x-ray-activatable titania nanoparticles (NPs) doped with lanthanides. Preferential incorporation of such materials into tumor tissue can enhance the effect of radiation therapy. Herein, the incorporation of gadolinium into the NPs is designed to optimize localized energy absorption from a conventional medical x-ray. This result is further optimized by the addition of other rare earth elements. Upon irradiation, energy is...

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Publisher copy:
10.1016/j.nano.2011.08.003

Authors


Townley, HE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Wakefield, G More by this author
Dobson, PJ More by this author
Journal:
Nanomedicine : nanotechnology, biology, and medicine
Volume:
8
Issue:
4
Pages:
526-536
Publication date:
2012-05-05
DOI:
EISSN:
1549-9642
ISSN:
1549-9634
URN:
uuid:3a8f9357-8f87-48ec-8a56-0c5512c2d70d
Source identifiers:
186510
Local pid:
pubs:186510

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