Journal article icon

Journal article

Beneficial coinfection can promote within-host viral diversity

Abstract:

In many viral infections, a large number of different genetic variants can coexist within a host, leading to more virulent infections that are better able to evolve antiviral resistance and adapt to new hosts. But how is this diversity maintained? Why do faster-growing variants not outcompete slower-growing variants, and erode this diversity? One hypothesis is if there are mutually beneficial interactions between variants, with host cells infected by multiple different viral genomes producing...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1093/ve/vey028

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
St Johns College
ORCID:
0000-0002-1175-7610
Segredo-Otero, EA More by this author
More by this author
ORCID:
0000-0002-1844-545X
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More from this funder
Funding agency for:
Leeks, A
Publisher:
Oxford University Press Publisher's website
Journal:
Virus Evolution Journal website
Volume:
4
Issue:
2
Pages:
Article: vey028
Publication date:
2018-10-01
Acceptance date:
2018-07-26
DOI:
ISSN:
2057-1577
Pubs id:
pubs:929816
URN:
uri:3a8b7213-070f-4f28-8bd6-31e490541a13
UUID:
uuid:3a8b7213-070f-4f28-8bd6-31e490541a13
Local pid:
pubs:929816

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP