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Beneficial coinfection can promote within-host viral diversity

Abstract:

In many viral infections, a large number of different genetic variants can coexist within a host, leading to more virulent infections that are better able to evolve antiviral resistance and adapt to new hosts. But how is this diversity maintained? Why do faster-growing variants not outcompete slower-growing variants, and erode this diversity? One hypothesis is if there are mutually beneficial interactions between variants, with host cells infected by multiple different viral genomes producing...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ve/vey028

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0002-1175-7610
More by this author
Role:
Author
ORCID:
0000-0002-1844-545X
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More from this funder
Funding agency for:
Leeks, A
Grant:
BB/M011224/1
More from this funder
Funding agency for:
Leeks, A
Grant:
BB/M011224/1
Publisher:
Oxford University Press Publisher's website
Journal:
Virus Evolution Journal website
Volume:
4
Issue:
2
Article number:
vey028
Publication date:
2018-10-01
Acceptance date:
2018-07-26
DOI:
ISSN:
2057-1577
Pmid:
30288300
Source identifiers:
929816
Language:
English
Keywords:
Pubs id:
pubs:929816
UUID:
uuid:3a8b7213-070f-4f28-8bd6-31e490541a13
Local pid:
pubs:929816
Deposit date:
2018-11-06

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