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PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

Abstract:

PARP1 regulates the repair of DNA single strand breaks (SSBs) generated directly, or during base excision repair (BER). However, the role of PARP2 in these and other repair mechanisms is unknown. Here, we report a requirement for PARP2 in stabilising replication forks that encounter BER intermediates through Fbh1- dependent regulation of Rad51. Whilst PARP2 is dispensable for tolerance of cells to SSBs or homologous recombination dysfunction, it is redundant with PARP1 in BER. Therefore, comb...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-03159-2

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Piberger, AL More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Stewart, GS More by this author
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Funding agency for:
Ronson, GE
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 746
Publication date:
2018-02-21
Acceptance date:
2018-01-24
DOI:
ISSN:
2041-1723
Pubs id:
pubs:821169
URN:
uri:3a83b73a-ad72-4528-9811-1d33c0be5785
UUID:
uuid:3a83b73a-ad72-4528-9811-1d33c0be5785
Local pid:
pubs:821169

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