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Thesis

Regulation of the human RNA nucleotidyl transferase ZCCHC11

Abstract:

Terminal uridylation of RNA 3ꞌ ends has recently been recognised as an important biological regulatory mechanism. The human terminal uridyl transferase ZCCHC11 was shown previously to uridylate and thereby regulate replication-dependent histone mRNAs and several miRNA precursors and mature miRNAs. Studies in cancer cell lines, mouse models and patient samples suggest that ZCCHC11 is a potential oncogene. However, very little is known about regulation of its expression and subcellular local...

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Institution:
University of Oxford
Research group:
NORBURY GROUP
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Pathology
Role:
Author

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Role:
Supervisor
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Funding agency for:
Erdem Akkaya
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:3a7f6958-cb91-493e-a1c3-2c22b6665f62
Local pid:
ora:10119
Language:
English
Keywords:
Subjects:

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