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Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis.

Abstract:

The aryl hydrocarbon receptor nuclear translocator (ARNT) is a basic helix-loop-helix transcription factor that forms heterodimers with the aryl hydrocarbon receptor (AhR) or hypoxia inducible factor-1alpha to activate transcription via xenobiotic response element or hypoxia response element, respectively. Thus, it plays a major role in two key biochemical pathways involved in tumor growth. We previously showed that estrogen receptor (ER)-negative breast cancer cell lines expressed a splice v...

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Publication status:
Published

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Blancher, C More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
7
Issue:
4
Pages:
818-823
Publication date:
2001-04-05
ISSN:
1078-0432
URN:
uuid:3a7c0bfa-dd24-4a87-9558-4faff5418953
Source identifiers:
114495
Local pid:
pubs:114495

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