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Journal article

Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice.

Abstract:

Boosting bacillus Calmette-Guérin (BCG)-primed mice with a recombinant adenovirus expressing Mycobacterium tuberculosis Ag 85A by different administration routes has very different effects on protection against aerosol challenge with M. tuberculosis. Mice boosted intradermally make very strong splenic CD4 and CD8 Th1 cytokine responses to Ag 85A, but show no change in lung mycobacterial burden over BCG primed animals. In contrast, intranasally boosted mice show greatly reduced mycobacterial b...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.181.7.4955

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
181
Issue:
7
Pages:
4955-4964
Publication date:
2008-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:3a78a10b-2300-4462-a53a-40f38d5617ef
Source identifiers:
34391
Local pid:
pubs:34391

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