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CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation

Abstract:

Human NK cells may be divided into a CD56dim subset and a CD56bright subset. In peripheral blood, CD56dim NK cells dominate, whereas in lymph nodes, CD56bright NK cells are more common. In this study we show that CD56bright NK cells accumulate within inflammatory lesions in a wide variety of clinical diseases affecting several different anatomical sites. We demonstrate that when activated by the monokines IL-12, IL-15, and IL-18, these NK cells promote TNF-α production by CD14+ monocytes in a...

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Authors


Dalbeth, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
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Journal:
Journal of Immunology
Volume:
173
Issue:
10
Pages:
6418-6426
Publication date:
2004-11-15
ISSN:
0022-1767
URN:
uuid:3a782a55-b4dd-4720-bf06-a7aa0d03506e
Source identifiers:
92661
Local pid:
pubs:92661
Language:
English

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