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Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo.

Abstract:

Lysis of infected cells by CD8(+) T cells is an important mechanism for the control of virus infections, but remains difficult to quantify in vivo. Here, we study the elimination kinetics of viral antigen-positive lymphocytes by antiviral CD8(+) T cells using flow cytometry and mathematical analysis. In mice acutely infected with lymphocytic choriomeningitis virus, more than 99.99 % of target cells were eliminated each day, corresponding to a half-life of 1.4 h. Even in mice exposed to virus ...

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Publication status:
Published

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Authors


Barchet, W More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Bocharov, G More by this author
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Journal:
European journal of immunology
Volume:
30
Issue:
5
Pages:
1356-1363
Publication date:
2000-05-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3a749d1e-b75e-4ed7-bbc1-e4293811ce44
Source identifiers:
12852
Local pid:
pubs:12852

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