An empirical exploration of the (delta mu)2 genetic distance for 213 human microsatellite markers.

Journal article

Microsatellites are now used ubiquitously as genetic markers. One important application is to the assessment of population subdivision and phylogenetic relatedness. Such applications require a method of estimation of genetic distance. Here we examine the most widely used measure of microsatellite genetic distance, Goldstein et al.'s delta-mu squared ([delta mu]2), with respect to a large data set of 213 markers typed across samples from four diverse human populations. We find that (delta mu)2...

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Authors: Cooper, G; Amos, W; Bellamy, R; Siddiqui, MR; Frodsham, A

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 65
• Issue: 4
• Pages: 1125-1133
• Publication date: 1999-10-01
• DOI: 10.1086/302574
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Gene Frequency; Phylogeny; Italy; Chromosome Mapping; Sensitivity and Specificity; Microsatellite Repeats; Time Factors; Alleles; Heterozygote; Humans; India; Sample Size; Genetic Linkage; Genetic Markers; Africa; Least-Squares Analysis