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Journal article

Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.

Abstract:

The nonclassical major histocompatibility complex class I molecule HLA-E acts as a ligand for CD94/NKG2 receptors on the surface of natural killer cells and a subset of T cells. HLA-E presents closely related nonameric peptide epitopes derived from the highly conserved signal sequences of classical major histocompatibility complex class I molecules as well as HLA-G. Their generation requires cleavage of the signal sequence by signal peptidase followed by the intramembrane-cleaving aspartic pr...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m305593200

Authors


Lemberg, MK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Martoglio, B More by this author
Journal:
The Journal of biological chemistry
Volume:
278
Issue:
36
Pages:
33747-33752
Publication date:
2003-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:3a6287ed-ce8e-4488-87ca-09af54bc66df
Source identifiers:
32392
Local pid:
pubs:32392

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