Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.

Journal article

The nonclassical major histocompatibility complex class I molecule HLA-E acts as a ligand for CD94/NKG2 receptors on the surface of natural killer cells and a subset of T cells. HLA-E presents closely related nonameric peptide epitopes derived from the highly conserved signal sequences of classical major histocompatibility complex class I molecules as well as HLA-G. Their generation requires cleavage of the signal sequence by signal peptidase followed by the intramembrane-cleaving aspartic pr...

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Authors: Bland, F; Lemberg, M; Mcmichael, A; Martoglio, B; Braud, V

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 278
• Issue: 36
• Pages: 33747-33752
• Publication date: 2003-09-01
• DOI: 10.1074/jbc.m305593200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Amino Acid Sequence; Aspartic Acid Endopeptidases; Cytosol; Acids; Flow Cytometry; Ligands; Protein Structure, Tertiary; Acetylcysteine; Serine Endopeptidases; Peptide Hydrolases; Alleles; Plasmids; Humans; Peptides; Transfection; Cysteine Proteinase Inhibitors; Molecular Sequence Data; Cell Line; Dose-Response Relationship, Drug; Protein Biosynthesis; Cysteine Endopeptidases; Transcription, Genetic; Proteasome Endopeptidase Complex; HLA Antigens; Epitopes; Membrane Proteins; HLA-G Antigens; Histocompatibility Antigens Class I; Multienzyme Complexes; Oligopeptides