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Journal article

UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.

Abstract:

piRNAs silence transposons during germline development. In Drosophila, transcripts from heterochromatic clusters are processed into primary piRNAs in the perinuclear nuage. The nuclear DEAD box protein UAP56 has been previously implicated in mRNA splicing and export, whereas the DEAD box protein Vasa has an established role in piRNA production and localizes to nuage with the piRNA binding PIWI proteins Ago3 and Aub. We show that UAP56 colocalizes with the cluster-associated HP1 variant Rhino,...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2012.09.040

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Journal:
Cell
Volume:
151
Issue:
4
Pages:
871-884
Publication date:
2012-11-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
366811
Language:
English
Keywords:
Pubs id:
pubs:366811
UUID:
uuid:3a59f76e-d91b-4206-bf0c-93612f56e4c0
Local pid:
pubs:366811
Deposit date:
2013-11-17

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