Journal article
UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.
- Abstract:
-
piRNAs silence transposons during germline development. In Drosophila, transcripts from heterochromatic clusters are processed into primary piRNAs in the perinuclear nuage. The nuclear DEAD box protein UAP56 has been previously implicated in mRNA splicing and export, whereas the DEAD box protein Vasa has an established role in piRNA production and localizes to nuage with the piRNA binding PIWI proteins Ago3 and Aub. We show that UAP56 colocalizes with the cluster-associated HP1 variant Rhino,...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.cell.2012.09.040
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Authors
Bibliographic Details
- Journal:
- Cell
- Volume:
- 151
- Issue:
- 4
- Pages:
- 871-884
- Publication date:
- 2012-11-01
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Source identifiers:
-
366811
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:366811
- UUID:
-
uuid:3a59f76e-d91b-4206-bf0c-93612f56e4c0
- Local pid:
- pubs:366811
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2012
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