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A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies.

Abstract:

The presence of serum bactericidal antibodies is a proven correlate of protection against systemic infection with the important human pathogen Neisseria meningitidis. We have identified three serogroup C N. meningitidis (MenC) isolates recovered from patients with invasive meningococcal disease that resist killing by bactericidal antibodies induced by the MenC conjugate vaccine. None of the patients had received the vaccine, which has been successfully introduced in countries in North America...

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Publisher copy:
10.1084/jem.20072577

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Journal:
The Journal of experimental medicine
Volume:
205
Issue:
6
Pages:
1423-1434
Publication date:
2008-06-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3a546e86-12c3-4890-abdb-6ba7011931c5
Source identifiers:
249487
Local pid:
pubs:249487

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