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An unusual metabolic myopathy: a malate-aspartate shuttle defect.

Abstract:

Studies on a 27-year-old man with a 3-year history of exercise-induced muscle pain, passage of red urine and elevated serum creatine kinase are described. Histological examination of a biopsy from quadriceps revealed non-specific myopathic changes with occasional clusters of subsarcolemmal mitochondria. The phosphorylase stain was normal. Phosphorous nuclear magnetic resonance (NMR) spectroscopy studies of gastrocnemius and flexor digitorum superficialis muscles showed no abnormalities at res...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Journal of the neurological sciences
Volume:
82
Issue:
1-3
Pages:
27-39
Publication date:
1987-12-01
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
Language:
English
Keywords:
Pubs id:
pubs:248116
UUID:
uuid:3a4e3773-a00d-429a-8655-dd544c46b802
Local pid:
pubs:248116
Source identifiers:
248116
Deposit date:
2012-12-19

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