Journal article
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
- Abstract:
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Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently dysregulated in cancer, they participate in gene fusions that generate diverse, frequ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 500.3KB)
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- Publisher copy:
- 10.1038/nrm.2016.143
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Authors
Funding
+ Uehara Memorial Foundation
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Funding agency for:
Fujisawa, T
Grant:
Fellowship (201330102
+ Wellcome Trust
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Funding agency for:
Filippakopoulos, P
Grant:
Career-Development Fellowship (095751/Z/11/Z
Ludwig Institute for Cancer Research
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Structural Genomics Consortium
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Reviews: Molecular Cell Biology Journal website
- Volume:
- 18
- Pages:
- 246–262
- Publication date:
- 2017-01-05
- Acceptance date:
- 2016-10-13
- DOI:
- EISSN:
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1471-0080
- ISSN:
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1471-0072
- Source identifiers:
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668372
Item Description
- Keywords:
- Pubs id:
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pubs:668372
- UUID:
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uuid:3a4e311c-2089-4dfb-a94c-da7c9314e336
- Local pid:
- pubs:668372
- Deposit date:
- 2017-01-06
Terms of use
- Copyright holder:
- Fujisawa and Filippakopoulos
- Copyright date:
- 2017
- Notes:
- © the Author(s), published by Nature Publishing Group. This is the accepted manuscript version of the article. The final version is available online from Nature at: [10.1038/nrm.2016.143]
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