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Journal article

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

Abstract:

Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently dysregulated in cancer, they participate in gene fusions that generate diverse, frequ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nrm.2016.143

Authors


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Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
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Department:
Oxford, MSD, NDM, Structural Genomics Consortium
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Funding agency for:
Filippakopoulos, P
Ludwig Institute for Cancer Research More from this funder
Structural Genomics Consortium More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews: Molecular Cell Biology Journal website
Volume:
18
Pages:
246–262
Publication date:
2017-01-05
Acceptance date:
2016-10-13
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
Pubs id:
pubs:668372
URN:
uri:3a4e311c-2089-4dfb-a94c-da7c9314e336
UUID:
uuid:3a4e311c-2089-4dfb-a94c-da7c9314e336
Local pid:
pubs:668372

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