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Heavy ions can enhance TGFβ mediated epithelial tomesenchymal transition

Abstract:

TGFβ is a key modulator of the Epithelial-Mesenchymal Transition (EMT), a process important in cancer progression and metastasis, which leads to the suppression of epithelial genes and expression of mesenchymal proteins. Ionizing radiation was found to specifically induce expression of the TGF-â1 isoform, which can modulate late post-radiation changes and increase the risk of tumor development and metastasis. Interactions between TGFβ induced EMT and DNA damage responses have not been fully e...

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Publisher copy:
10.1269/jrr.11121

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Journal:
Journal of Radiation Research
Volume:
53
Issue:
1
Pages:
51-57
Publication date:
2012-01-01
DOI:
EISSN:
1349-9157
ISSN:
0449-3060
Source identifiers:
343073
Language:
English
Pubs id:
pubs:343073
UUID:
uuid:3a4cc516-1cd8-4827-8074-1d7046cbda4d
Local pid:
pubs:343073
Deposit date:
2013-11-17

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