Journal article
Heavy ions can enhance TGFβ mediated epithelial tomesenchymal transition
- Abstract:
-
TGFβ is a key modulator of the Epithelial-Mesenchymal Transition (EMT), a process important in cancer progression and metastasis, which leads to the suppression of epithelial genes and expression of mesenchymal proteins. Ionizing radiation was found to specifically induce expression of the TGF-â1 isoform, which can modulate late post-radiation changes and increase the risk of tumor development and metastasis. Interactions between TGFβ induced EMT and DNA damage responses have not been fully e...
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Bibliographic Details
- Journal:
- Journal of Radiation Research More from this journal
- Volume:
- 53
- Issue:
- 1
- Pages:
- 51-57
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1349-9157
- ISSN:
-
0449-3060
Item Description
- Language:
-
English
- Pubs id:
-
pubs:343073
- UUID:
-
uuid:3a4cc516-1cd8-4827-8074-1d7046cbda4d
- Local pid:
-
pubs:343073
- Source identifiers:
-
343073
- Deposit date:
-
2013-11-17
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- Copyright date:
- 2012
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