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Journal article

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication.

Abstract:

BACKGROUND AND AIMS: Chronic hepatitis C is a global health problem with an estimated 170 million HCV infected individuals at risk of progressive liver disease and hepatocellular carcinoma (HCC). Autotaxin (ATX) is a phospholipase with diverse roles in physiological and pathological processes including inflammation and oncogenesis. Clinical studies have reported increased ATX expression in chronic hepatitis C, however, the pathways regulating ATX and its role in the viral life cycle are not w...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.jhep.2017.01.009

Authors


Farquhar, MJ More by this author
Humphreys, IS More by this author
Wilson, GK More by this author
Bhattacharya, B More by this author
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Medical Research Council More from this funder
NIHR Birmingham Liver Biomedical Research Unit More from this funder
European Union More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Hepatology Journal website
Volume:
66
Issue:
5
Pages:
919-929
Publication date:
2017-01-23
Acceptance date:
2017-01-08
DOI:
EISSN:
1600-0641
ISSN:
0168-8278
Pubs id:
pubs:675246
URN:
uri:3a419b71-51fb-47d3-b1ea-3cb2ceb98624
UUID:
uuid:3a419b71-51fb-47d3-b1ea-3cb2ceb98624
Local pid:
pubs:675246
Language:
English
Keywords:

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