- Abstract:
-
A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential risk in the general population. We hypothesized the underlying cause to be moderate differences in ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.celrep.2014.07.020
-
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- Journal:
- Cell reports
- Volume:
- 8
- Issue:
- 4
- Pages:
- 983-990
- Publication date:
- 2014-08-05
- DOI:
- EISSN:
-
2211-1247
- ISSN:
-
2211-1247
- URN:
-
uuid:3a3f0295-da76-49da-82d8-42a47ac76abb
- Source identifiers:
-
480581
- Local pid:
- pubs:480581
- Language:
- English
- Copyright date:
- 2014
Journal article
A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.
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