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A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

Abstract:

A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential risk in the general population. We hypothesized the underlying cause to be moderate differences in ...

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Publication status:
Published

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Journal:
Cell reports
Volume:
8
Issue:
4
Pages:
983-990
Publication date:
2014-08-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:3a3f0295-da76-49da-82d8-42a47ac76abb
Source identifiers:
480581
Local pid:
pubs:480581
Language:
English

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