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Clearing asymptomatic parasitaemia increases the specificity of the definition of mild febrile malaria.

Abstract:

In clinical trials, the specificity of the disease endpoint is critical to an accurate estimate of vaccine efficacy. We used a logistic regression model to analyse parasite densities among children before and after treatment with antimalarials, in order to estimate the impact that clearing asymptomatic parasitaemia had on the specificity of the endpoint of febrile malaria. The malaria attributable fever fraction was higher after antimalarial treatment (i.e. fever and parasitaemia were more li...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
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Journal:
Vaccine
Volume:
25
Issue:
48
Pages:
8198-8202
Publication date:
2007-11-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:3a38d471-09a7-450d-9f09-4abe8bfd54af
Source identifiers:
40566
Local pid:
pubs:40566

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