Lymphoid proliferations of indeterminate malignant potential arising in adults with common variable immunodeficiency disorders: unusual case studies and immunohistological review in the light of possible causative events.

Journal article

Patients with common variable immunodeficiency disorders (CVIDs) who developed B cell lymphoproliferation of indeterminate malignant potential are described in order to raise a discussion of the relationship between infection and lymphoproliferation in infection prone patients. Those with CVID are at risk of developing either polyclonal or monoclonal lymphoproliferation in part due to the dysregulation of their adaptive immune systems. The aetiologies of the lymphoproliferations are unknown b...

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Authors: da Silva, S; Resnick, E; Lucas, M; Lortan, J; Patel, S

• Publication status: Published
• Journal: Journal of clinical immunology
• Volume: 31
• Issue: 5
• Pages: 784-791
• Publication date: 2011-10-01
• DOI: 10.1007/s10875-011-9565-z
• EISSN: 1573-2592
• ISSN: 0271-9142
• Language: English
• Keywords: Lymphoma, B-Cell, Marginal Zone; Fatal Outcome; Adult; Herpesvirus 4, Human; Epstein-Barr Virus Infections; B-Lymphocytes; Autoimmunity; Precancerous Conditions; Diagnosis, Differential; Skin; Common Variable Immunodeficiency; Female; Middle Aged; Aspergillus fumigatus; Humans; Remission, Spontaneous; Cell Transformation, Neoplastic; Cell Transformation, Viral; Aspergillosis; Lymphoproliferative Disorders; Aged; Lung Neoplasms; Male; Lung