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Thesis

Role of OX40-OX40L interactions in the immune response to solid organ allografts

Abstract:

Transplantation is the treatment of choice for end stage organ failure however current immunosuppressive therapies whilst effective at preventing acute allograft rejection, fail to prevent late graft loss due to chronic rejection and are associated with an increased risk of infection and malignancy. Therefore there is a clear unmet clinical need for improved strategies to prevent allograft rejection.

OX40 is a member of the TNFR superfamily that has potent costimulatory properties. ...

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Institution:
University of Oxford
Research group:
Transplantation reserach immunology group
Oxford college:
Green College
Department:
Medical Sciences Division - Surgery
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Gillian Kinnear
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:3a1f1658-eed2-4d5f-9331-d0ed884ec7ca
Local pid:
ora:7298
Language:
English
Keywords:
Subjects:

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