Transplantation is the treatment of choice for end stage organ failure however current immunosuppressive therapies whilst effective at preventing acute allograft rejection, fail to prevent late graft loss due to chronic rejection and are associated with an increased risk of infection and malignancy. Therefore there is a clear unmet clinical need for improved strategies to prevent allograft rejection.
OX40 is a member of the TNFR superfamily that has potent costimulatory properties. ...Expand abstract
- Publication date:
- Type of award:
- Level of award:
- Local pid:
- Copyright holder:
- Gillian Kinnear
- Copyright date:
- This thesis is not currently available in ORA.
Role of OX40-OX40L interactions in the immune response to solid organ allografts
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record