Journal article
NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone
- Abstract:
-
Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression. At the start of primary ossification, TrkA-positive axons were observed at peri...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Craig H. Neilsen Foundation
More from this funder
Department of Veterans Affairs
More from this funder
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 16
- Issue:
- 10
- Pages:
- 2723-2735
- Publication date:
- 2016-08-25
- Acceptance date:
- 2016-07-31
- DOI:
- ISSN:
-
2211-1247
Item Description
- Keywords:
- Pubs id:
-
pubs:641562
- UUID:
-
uuid:3a1d9fe8-20e3-4635-99a3-3b9fbe4b185c
- Local pid:
- pubs:641562
- Source identifiers:
-
641562
- Deposit date:
- 2016-09-05
Terms of use
- Copyright holder:
- Tomlinson et al
- Copyright date:
- 2016
- Notes:
- This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record