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Impaired clinical response in a patient with uncomplicated falciparum malaria who received poor-quality and underdosed intramuscular artemether.

Abstract:

We describe an adult with uncomplicated Plasmodium falciparum malaria who did not improve clinically despite 5 days of intramuscular artemether therapy. He was prescribed a lower dose (kg body weight) than that recommended, and a vial from the packet contained only 74% of the artemether dose as stated by the manufacturer. The combination of underdosing, poor-quality drug, and the intrinsic low bioavailability of artemether may have contributed to his poor clinical response. Analysis of the pa...

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Publication status:
Published

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Authors


Keoluangkhot, V More by this author
Nyadong, L More by this author
Fernández, FM More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
78
Issue:
4
Pages:
552-555
Publication date:
2008-04-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:3a11bf44-bc4f-4d33-9c93-b080f771d3b9
Source identifiers:
7132
Local pid:
pubs:7132

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