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Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.

Abstract:

The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presentation by the antigen-presenting molecule CD1d. To monitor the ability of CD1d to present the glycolipids, we have used a phage display strategy to generate recombinant antibodie...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200737518

Authors


Denkberg, G More by this author
Stronge, VS More by this author
Pittoni, P More by this author
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Journal:
European journal of immunology
Volume:
38
Issue:
3
Pages:
829-840
Publication date:
2008-03-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3a0f7863-a738-4b49-a9bb-66e452409648
Source identifiers:
34120
Local pid:
pubs:34120

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