Journal article
Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.
- Abstract:
-
The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presentation by the antigen-presenting molecule CD1d. To monitor the ability of CD1d to present the glycolipids, we have used a phage display strategy to generate recombinant antibodie...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.200737518
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 38
- Issue:
- 3
- Pages:
- 829-840
- Publication date:
- 2008-03-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:3a0f7863-a738-4b49-a9bb-66e452409648
- Source identifiers:
-
34120
- Local pid:
- pubs:34120
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2008
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