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Detecting and modulating the NF-kB activity in human immune cells: generation of human cell lines with altered levels of NF-kappaB.

Abstract:

NF-kappaB plays a pivotal role in immunity and inflammation and is considered to be a promising candidate for drug development. However, global suppression of NF-kappaB may have undesirable side-effects. Our data and the results of others suggest that each of the five NF-kappaB subunits may have a specific function in controlling the expression of inflammatory mediators in immune cells. Identifying the role for each NF-kappaB subunit in primary human immune cells will allow a more targeted ap...

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Publisher copy:
10.1007/978-1-60327-530-9_4

Authors


Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
512
Pages:
39-54
Publication date:
2009-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:3a07007f-d854-41ee-bbc1-812d2b1be75b
Source identifiers:
226764
Local pid:
pubs:226764

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