- Abstract:
-
NF-kappaB plays a pivotal role in immunity and inflammation and is considered to be a promising candidate for drug development. However, global suppression of NF-kappaB may have undesirable side-effects. Our data and the results of others suggest that each of the five NF-kappaB subunits may have a specific function in controlling the expression of inflammatory mediators in immune cells. Identifying the role for each NF-kappaB subunit in primary human immune cells will allow a more targeted ap...
Expand abstract - Publisher copy:
- 10.1007/978-1-60327-530-9_4
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- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Volume:
- 512
- Pages:
- 39-54
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
-
1940-6029
- ISSN:
-
1064-3745
- URN:
-
uuid:3a07007f-d854-41ee-bbc1-812d2b1be75b
- Source identifiers:
-
226764
- Local pid:
- pubs:226764
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Detecting and modulating the NF-kB activity in human immune cells: generation of human cell lines with altered levels of NF-kappaB.
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