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Journal article

Anti-angiogenic effect of tamoxifen combined with epirubicin in breast cancer patients.

Abstract:

Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) are the key factors mediating neo-vascularization. They are often coexpressed in breast cancer. Sex steroids may stimulate angiogenesis via the estrogen receptor (ER) pathway. We investigated to compare the effects of the addition of tamoxifen to epirubicin versus epirubicin alone on VEGF and VEGFR2 expression in breast cancer patients. The expression of VEGF and VEGFR2 was assessed on tis...

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Publication status:
Published

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Publisher copy:
10.1007/s10549-010-1063-0

Authors


Generali, D More by this author
Brizzi, MP More by this author
Bersiga, A More by this author
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Journal:
Breast cancer research and treatment
Volume:
123
Issue:
3
Pages:
795-804
Publication date:
2010-10-05
DOI:
EISSN:
1573-7217
ISSN:
0167-6806
URN:
uuid:39f399df-56e5-4c2c-862c-83c9a77aac8e
Source identifiers:
125067
Local pid:
pubs:125067

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