Journal article
Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients
- Abstract:
-
Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by muscle weakness and caused by pathogenic autoantibodies that bind to membrane proteins at the neuromuscular junction. Most patients have autoantibodies against the acetylcholine receptor (AChR), but a subset of patients have autoantibodies against muscle-specific tyrosine kinase (MuSK) instead. MuSK is an essential component of the pathway responsible for synaptic differentiation, which is activated by nerve-released agr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.4MB)
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(Version of record, pdf, 448.0KB)
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- Publisher copy:
- 10.1172/jci.insight.127167
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Funding
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI Insight Journal website
- Volume:
- 4
- Issue:
- 12
- Article number:
- e127167
- Publication date:
- 2019-06-20
- Acceptance date:
- 2019-05-10
- DOI:
- ISSN:
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2379-3708
Item Description
- Keywords:
- Pubs id:
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pubs:998774
- UUID:
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uuid:39f29e9c-363f-4fa6-9711-bc766f4a8fb8
- Local pid:
- pubs:998774
- Source identifiers:
-
998774
- Deposit date:
- 2019-05-15
Terms of use
- Copyright holder:
- Takata et al
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 Takata et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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