Journal article
The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: A review of the evidence
- Abstract:
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Background Scrub typhus is a neglected tropical disease that causes acute febrile illness. Diagnosis is made based upon serology, or detection of the causative agent–Orientia tsutsugamushi–using PCR or in vitro isolation. The enzyme-linked immunosorbent assay (ELISA) is an objective and reproducible means of detecting IgM or IgG antibodies. However, lack of standardization in ELISA methodology, as well as in the choice of reference test with which the ELISA is compared, calls... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Version of record, pdf, 804.4KB)
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- Publisher copy:
- 10.1371/journal.pntd.0007158
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLOS Neglected Tropical Diseases Journal website
- Volume:
- 13
- Issue:
- 2
- Pages:
- e0007158
- Publication date:
- 2019-02-04
- Acceptance date:
- 2019-01-15
- DOI:
- EISSN:
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1935-2735
- ISSN:
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1935-2727
- Pmid:
-
30716070
Item Description
- Language:
- English
- Pubs id:
-
pubs:969510
- UUID:
-
uuid:39efaac3-3c9d-4168-ad7e-606b80131c0d
- Local pid:
- pubs:969510
- Source identifiers:
-
969510
- Deposit date:
- 2019-03-05
Terms of use
- Copyright holder:
- Saraswati et al
- Copyright date:
- 2019
- Notes:
- © 2019 Saraswati et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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