Journal article
microRNAs in the lymphatic endothelium: Master regulators of lineage plasticity and inflammation
- Abstract:
- microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 726.2KB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2017.00104
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 8
- Issue:
- FEB
- Pages:
- 104
- Publication date:
- 2017-02-09
- Acceptance date:
- 2017-01-20
- DOI:
- EISSN:
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1664-3224
- Pmid:
-
28232833
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:821760
- UUID:
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uuid:39e24aa1-9dbe-4084-abf7-3e188b38ff76
- Local pid:
-
pubs:821760
- Source identifiers:
-
821760
- Deposit date:
-
2018-05-16
Terms of use
- Copyright holder:
- Coles et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Yee, Coles and Lagos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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