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Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.

Abstract:

Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an important role in the detoxification of xenobiotics bearing a carbonyl group. The two monomeric NADPH-dependent human isoforms of cytosolic carbonyl reductase CBR1 and CBR3 show a sequence similarity of 85% on the amino acid level, which is definitely high if compared to the low similarities usually observed among other members of the SDR superfamily (15-30%). Desp...

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Journal:
Chemico-biological interactions
Volume:
178
Issue:
1-3
Pages:
234-41
Publication date:
2009-01-01
ISSN:
1872-7786
URN:
uuid:39e196d8-04c1-4f26-8a4e-d39f31354140
Local pid:
SGC:19061875

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