- Abstract:
-
Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an important role in the detoxification of xenobiotics bearing a carbonyl group. The two monomeric NADPH-dependent human isoforms of cytosolic carbonyl reductase CBR1 and CBR3 show a sequence similarity of 85% on the amino acid level, which is definitely high if compared to the low similarities usually observed among other members of the SDR superfamily (15-30%). Desp...
Expand abstract - Journal:
- Chemico-biological interactions
- Volume:
- 178
- Issue:
- 1-3
- Pages:
- 234-41
- Publication date:
- 2009
- ISSN:
-
1872-7786
- URN:
-
uuid:39e196d8-04c1-4f26-8a4e-d39f31354140
- Local pid:
- SGC:19061875
- Language:
- English
- Subjects:
- Copyright date:
- 2009
Journal article
Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.
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