Journal article
An activity-based probe targeting non-catalytic, highly conserved amino acid residues within bromodomains
- Abstract:
-
Bromodomain‐containing proteins are epigenetic modulators involved in a wide range of cellular processes, from recruitment of transcription factors to pathological disruption of gene regulation and cancer development. Since the druggability of these acetyl‐lysine reader domains was established, efforts were made to develop potent and selective inhibitors across the entire family. Here we report the development of a small molecule‐based approach to covalently modify recombinant and endogenous ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
Actions
Access Document
- Files:
-
-
(pdf, 3.2MB)
-
(pdf, 3.5MB)
-
- Publisher copy:
- 10.1002/anie.201807825
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Angewandte Chemie International Edition Journal website
- Volume:
- 58
- Issue:
- 4
- Pages:
- 1007-1012
- Publication date:
- 2018-12-27
- Acceptance date:
- 2018-12-27
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- Pubs id:
-
pubs:954996
- URN:
-
uri:39db9ad9-8705-4423-8ca6-f035504f2873
- UUID:
-
uuid:39db9ad9-8705-4423-8ca6-f035504f2873
- Local pid:
- pubs:954996
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- D'Ascenzio et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
If you are the owner of this record, you can report an update to it here: Report update to this record