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Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells.

Abstract:

4-1BB is expressed on invariant (i)NKT cells, but its role is unclear. We showed previously that iNKT cells are involved in control of monocyte numbers during influenza A virus (IAV) infection and now question the role of the 4-1BB costimulatory pathway in the cross-talk between these cells. We found that iNKT cells and monocytes interact to promote expression of 4-1BB and 4-1BBL, respectively. Blockade of 4-1BB/L pathway under resting coculture conditions increased apoptosis of iNKT cells an...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1302385

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
American Association of Immunologists
Journal:
Journal of Immunology
Volume:
192
Issue:
8
Pages:
3898-3907
Publication date:
2014-04-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
457837
Language:
English
Keywords:
Pubs id:
pubs:457837
UUID:
uuid:39d05014-7301-4087-9199-1fc73b63ab49
Local pid:
pubs:457837
Deposit date:
2014-05-10

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