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Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Abstract:

IGF-I is considered a primary inhibitor of GH secretion. Insulin may also play an important role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and release in primary pituitary cell cultures and insulin is negatively correlated with GH levels in vivo. However, understanding the relative contribution insulin and IGF-I exert on controlling GH secretion has been hampered by the fact that circulating insulin and IGF-I are regulated in parallel and insulin (INSR) an...

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Publication status:
Published

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Publisher copy:
10.1210/en.2013-1261

Authors


Gahete, MD More by this author
Córdoba-Chacón, J More by this author
Brüning, JC More by this author
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Journal:
Endocrinology
Volume:
154
Issue:
7
Pages:
2410-2420
Publication date:
2013-07-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:39ce4cb6-a5e8-4285-8c02-1d3ec8c1d37e
Source identifiers:
371351
Local pid:
pubs:371351

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