Journal article
Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.
- Abstract:
-
IGF-I is considered a primary inhibitor of GH secretion. Insulin may also play an important role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and release in primary pituitary cell cultures and insulin is negatively correlated with GH levels in vivo. However, understanding the relative contribution insulin and IGF-I exert on controlling GH secretion has been hampered by the fact that circulating insulin and IGF-I are regulated in parallel and insulin (INSR) an...
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- Publication status:
- Published
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- Publisher copy:
- 10.1210/en.2013-1261
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Authors
Bibliographic Details
- Journal:
- Endocrinology
- Volume:
- 154
- Issue:
- 7
- Pages:
- 2410-2420
- Publication date:
- 2013-07-05
- DOI:
- EISSN:
-
1945-7170
- ISSN:
-
0013-7227
- URN:
-
uuid:39ce4cb6-a5e8-4285-8c02-1d3ec8c1d37e
- Source identifiers:
-
371351
- Local pid:
- pubs:371351
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2013
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