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N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

Abstract:

Structure-based drug design has led to the discovery of a number of glucose analogue inhibitors of glycogen phosphorylase that have an increased affinity compared to alpha-D-glucose (Ki = 1.7 mM). The best inhibitor in the class of N-acyl derivatives of beta-D-glucopyranosylamine, N-acetyl-beta-D-glucopyranosylamine (1-GlcNAc), has been characterized by kinetic, ultracentrifugation, and crystallographic studies. 1-GlcNAc acts as a competitive inhibitor for both the b (Ki = 32 microM) and the ...

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Publication status:
Published

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Publisher copy:
10.1002/pro.5560041203

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Journal:
Protein science : a publication of the Protein Society
Volume:
4
Issue:
12
Pages:
2469-2477
Publication date:
1995-12-01
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
Source identifiers:
45024
Language:
English
Keywords:
Pubs id:
pubs:45024
UUID:
uuid:39c7e511-516d-42c6-a94f-983c50cd209f
Local pid:
pubs:45024
Deposit date:
2012-12-19

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