Journal article
Influence of propofol on isolated neonatal rat carotid body glomus cell response to hypoxia and hypercapnia
- Abstract:
-
In humans the intravenous anaesthetic propofol depresses ventilatory responses to hypoxia and CO2. Animal studies suggest that this may in part be due to inhibition of synaptic transmission between chemoreceptor glomus cells of the carotid body and the afferent carotid sinus nerve. It is however unknown if propofol can also act directly on the glomus cell. Here we report that propofol can indeed inhibit intracellular Ca2+ responses to hypoxia and hypercapnia in isolated rat glomus cells. Neit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Mason Medical Research Foundation
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Respiratory Physiology and Neurobiology Journal website
- Volume:
- 260
- Issue:
- February 2019
- Pages:
- 17-27
- Publication date:
- 2018-10-30
- Acceptance date:
- 2018-10-29
- DOI:
- ISSN:
-
1569-9048
- Pmid:
-
30389452
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
943803
- Local pid:
- pubs:943803
- Deposit date:
- 2020-10-30
Terms of use
- Copyright holder:
- O'Donohoe et al.
- Copyright date:
- 2018
- Rights statement:
- ©2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
- Licence:
- CC Attribution (CC BY)
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