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Journal article

Epitope exposure on functional, oligomeric HIV-1 gp41 molecules.

Abstract:

We have used cells infected with the HIV-1 molecular clone HX10 to study the binding of monoclonal antibodies (mAbs) to different epitopes within the extracellular domain of the HIV-1 transmembrane glycoprotein gp41. Gp41 mAb binding to the infected cells at 4 degrees was variable but weaker than the binding of an anti-gp120/V3 loop mAb and increased substantially for three of the gp41 antibodies at 37 degrees. Treatment of the cells with soluble CD4 (sCD4) at 37 degrees increased gp41 mAb bi...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Virology
Volume:
206
Issue:
1
Pages:
713-717
Publication date:
1995-01-01
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
Source identifiers:
29592
Language:
English
Keywords:
Pubs id:
pubs:29592
UUID:
uuid:39bf2ab1-7a8b-4817-b7d0-e403de66e0b4
Local pid:
pubs:29592
Deposit date:
2012-12-19

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