Journal article icon

Journal article

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Abstract:

Here we describe a previously unknown form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra. Mice homozygous for this mutation showed enhanced susceptibility to bacterial and viral infection and diminished numbers of T cells and inflammatory monocytes that failed to proliferate after infection and died via the intrinsic apoptotic pathway in response to diverse proliferative stimuli. They also had a greater proportion of T cells poised to repli...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/ni.1847

Authors


Croker, BA More by this author
Expand authors...
Journal:
Nature immunology
Volume:
11
Issue:
4
Pages:
335-343
Publication date:
2010-04-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:39bf148a-44de-4326-a558-3b4b51b92cae
Source identifiers:
418824
Local pid:
pubs:418824

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP