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Journal article

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Abstract:

Here we describe a previously unknown form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra. Mice homozygous for this mutation showed enhanced susceptibility to bacterial and viral infection and diminished numbers of T cells and inflammatory monocytes that failed to proliferate after infection and died via the intrinsic apoptotic pathway in response to diverse proliferative stimuli. They also had a greater proportion of T cells poised to repli...

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Publisher copy:
10.1038/ni.1847

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Journal:
Nature immunology
Volume:
11
Issue:
4
Pages:
335-343
Publication date:
2010-04-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
418824
Language:
English
Keywords:
Pubs id:
pubs:418824
UUID:
uuid:39bf148a-44de-4326-a558-3b4b51b92cae
Local pid:
pubs:418824
Deposit date:
2013-11-16

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